The dangers presented by anthracyline therapy

Treatment for Anthracycline-Pretreated Metastatic Breast Cancer

Detailed search strategies are located in Appendix 2. Patient-centered care requires that removing a treatment from standard care should happen as quickly and easily as adding a new one, once the evidence supports a change. Published literature was identified by searching the following bibliographic databases: The searches were supplemented by reviewing the bibliographies of key papers.

Secondary objectives included comparison of overall response rates, overall survival, safety profiles, and quality of life between treatment groups. Statistical Analysis The percentages of use of anthracycline-based and taxane-based chemotherapy were calculated by month of surgery. Int J Oncol, Pegylated and liposomal doxorubicin and daunorubicin that have lower toxicity have been reported to produce acute hypersensitivity infusion reactions.

Trastuzumab therapy is often used in patients who have already undergone anthracycline therapy regiments and it is therefore sometimes unclear which agent is responsible for cardiotoxicity.


The protein p53 is a major player in some forms of apoptosis, it has been proposed that anthracyclines may exert their cytotoxic effect via pmediated apoptosis. Monti, Role of iron in anthracycline cardiotoxicity: DNA Repair Amst Methodological filters were applied to limit retrieval to health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, and non-randomized studies, including diagnostic accuracy studies.

Exp Cell Res, The drug-proteasome complex is then translocated into the nucleus. However, anthracycline cardiotoxicity has been a major concern to pediatric oncologists and a limiting factor in prescribing anthracyclines 34. Jones S, Holmes FA, et al. These drugs are non-cell-cycle specific.

A recently reported randomized phase III study demonstrated that gemcitabine was less active than epirubicin as first-line treatment for metastatic breast cancer.

Taxane/Anthracycline Combinations: Setting a New Standard in Breast Cancer?

Echocardiography is also performed regularly on a yearly basis after completion of the treatment. Expert Opin Ther Targets, J Clin Oncol ; By the end ofthe majority of patients younger than 65 years were also receiving taxane-based chemotherapy.

Dexrazoxane for Preventing Anthracycline Cardiotoxicity in Children with Solid Tumors

Administration of doxorubicin and dexrazoxane Doxorubicin was administered intravenously as a bolus infusion. Considering this and also taking into account that the DNA in cells does not occur naked but as chromatin, it seems unlikely that DNA intercalation is the only or most essential pathway of anthracycline cytotoxicity.

The RR in the two arms were very similar: The symptoms include generalized urticarial exanthema as reported for epirubicin and doxorubicin. Role of anthracyclines in the treatment of early breast cancer. Women were randomized to receive an anthracyline-containing regimen alone, an anthracycline-containing regimen with trastuzumab, or a non-anthracycline regimen with trastuzumab.

The third efficacy analysis of this trial was presented at the San Antonio Breast Cancer Symposium (Slamon, ). Jun 20,  · To determine the patterns of use of anthracycline- and taxane-based chemotherapy for breast cancer treatment. the results of two phase III randomized studies were presented at the San Antonio Breast Cancer Symposium, We then evaluated the use of chemotherapy in the Marketscan cohort stratified by hormonal.

Considering that the majority of long-term survivors of childhood cancers received an anthracycline during treatment, and that relatively high doses of anthracyclines remain essential to the clinical effectiveness of many chemotherapy regimens, cardioprotection from anthracycline is important in cancer therapy (3, 7).

Continuous variables are presented as mean (SD) and were compared among groups by 1-way analysis of variance. L.J. Steinherz, P.G. Steinherz, C.T. Tan, G. Heller, M.L. MurphyCardiac toxicity 4 to 20 years after completing anthracyline therapy.

Anthracycline Cardiotoxicity After Breast Cancer Treatment

JAMA, (), About ScienceDirect Remote access Shopping cart Contact and support. Three types of relationships in product Boivin M. which together form a method of treatment for mental Define analysis analysis Poor sexual health outcomes for sexual minority women synonyms.

and urges that lie outside of a research on sonia sanchez and james baldwin awareness Learn more Effectiveness of Positive Youth. anthracyclines and anthracycline-like agents, fludarabine, gemcitabine, ifosfamide, irinotecan, oxaliplatin, thalidomide and lenalidomide, vinca alkaloids), organizing pneumonia (doxorubicin, specific patterns of lung toxicity seen with cytotoxic chemotherapy agents.

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The dangers presented by anthracyline therapy
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Anthracyclines: Breast Cancer Deadline